(S)-(-)-1 2-Diaminopropane dihydrochloride (CAS# 19777-66-3)
Khatarta iyo Badbaadada
| Xeerarka Khatarta | R36/37/38 - Waxay ka xanaajisaa indhaha, habka neefsashada iyo maqaarka. R23/24/25 - Sunta neefsashada, taabashada maqaarka iyo haddii la liqo. |
| Sharaxaada Badbaadada | S26 - Haddii ay dhacdo in indhaha la taabto, isla markiiba ku raaci biyo badan oo raadso talo caafimaad. S36 - Xidho dhar ilaalin ku habboon. S45 - Haddii ay dhacdo shil ama haddii aad dareento xanuun, raadso talo caafimaad isla markiiba (tus calaamadda mar kasta oo ay suurtagal tahay.) S36/37/39 - Xidho dhar ilaalin ku haboon, galoofyada iyo ilaalinta indhaha/wejiga. |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-21 |
| Koodhka HS | 29212900 |
(S)-(-)-1 2-Diaminoropane dihydrochloride (CAS# 19777-66-3) Macluumaad
| Dulmar | (S) - (-) diaaminopropane dihydrochloride waxaa loo isticmaali karaa sida dhexdhexaadinta dawooyinka dawooyinka, sida diyaarinta Dexrazoxane, waa dextrorotatory enantiomer ee daawada antitumor razoxane. Daawooyinka ilaalinta wadnaha, kiliinikada ee Kahortagga daawooyinka kansarka anthracycline ee ay keento sunta wadnaha iyo leukemia ee carruurta oo ay ugu wacan tahay daawayn kiimoterabi oo uu sababay dhaawaca wadnaha, badiyaa sida adjuvant ee daawaynta kansarka. |
| Isticmaal | (S)-(-)-diaminopropane Dihydrochloride waa dhexdhexaad dabiici ah, waxaa lagu diyaarin karaa falcelinta D- (-) tartaric acid iyo propylenediamine. Diamine-ka ayaa loo adeegsaday isku-dhafka xeryahooda imidazoline ee chiral |
| diyaarinta | diyaarinta (S) - (-) diaminopropane dihydrochloride: ku dar 30.0gD-(-)-tartaric acid iyo 8.0 ml oo biyo ah iyo g (±) -1, 2-propanediamine ee weelka falcelinta, walaaq si aad u milmaan, qabow, ku dar Hoos-u-dhac, heerkulka ayaa kor loogu qaaday dib-u-soo-celinta 2 saacadood iyadoo la walaaqayo. Walaaqdii waa la joojiyay, heerkulkuna wuxuu kor u kacay 80 ° C. 1 saac. Ka dib, heerkulku si tartiib tartiib ah ayaa loo dejiyay heerkulka qolka, nuugista la sifeeyay, iyo faakuum la qalajiyey si loo helo 16.1g of (S) -1, 2-propanediamine ditartrate. Ku dar 16.1g oo ah (S) -1, 2-propanediamine ditartrate iyo biyo ah weelka falcelinta, ku milmi kulaylka, ka dibna ku dar xal 7.43g oo chloride potassium ah iyo 20ml oo biyo ah, isku dar ah ayaa lagu walaaqay 70 °c 2 saacadood. Kadib qaboojinta, qaboojiyaha ayaa loo oggolaaday inuu u istaago crystallization. Shaandhaynta waxaa lagu sifeeyay nuugid waxaana lagu miiray qallayl hoos yimaada cadaadiska si loo siiyo 84% G ee jaalaha adag (3), dhalidda 4.02, [α] 20D = - ° (C = 1%, H2O). |
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