Papaverine Hydrochloride (CAS#61-25-6)
Xeerarka Khatarta | R22 - Waxyeelo leh haddii la liqo R34 - Waxay sababtaa gubashada R11 - Aad u guban kara |
Sharaxaada Badbaadada | S22 - Ha neefsan boorka. S45 - Haddii ay dhacdo shil ama haddii aad dareento xanuun, raadso talo caafimaad isla markiiba (tus calaamadda mar kasta oo ay suurtagal tahay.) S36/37/39 - Xidho dhar ilaalin ku haboon, galoofyada iyo ilaalinta indhaha/wejiga. S26 - Haddii ay dhacdo in indhaha la taabto, isla markiiba ku raaci biyo badan oo raadso talo caafimaad. S16 - Ka fogow ilaha dabka. |
Aqoonsiga UN-ka | UN 1544 6.1/PG 3 |
WGK Germany | 1 |
RTECS | NW8575000 |
FLUKA BRAND F CODES | 8 |
TSCA | Haa |
Koodhka HS | 29391900 |
Heerka khatarta | 6.1 |
Kooxda Baakadaha | III |
Sunta | LD50 ee jiirarka, jiirka (mg/kg): 27.5, 20 iv; 150,370 sc (Lewis) |
Papaverine Hydrochloride (CAS#61-25-6)
Papaverine hydrochloride, lambarka CAS 61-25-6, waa xarun muhiim ah oo ku taal goobta daawada.
Marka laga eego aragtida hantida kiimikada, waa qaabka hydrochloride ee papaverine, iyo qaab-dhismeedka kiimikada ayaa go'aaminaya sifooyinkeeda. Habaynta atamka iyo habaynta curaarta kiimikaad ee qaab dhismeedka molecular waxay siinaysaa xasilooni iyo falcelin gaar ah. Muuqaalku guud ahaan waa caddaan ilaa budada crystalline jaalaha ah, taas oo ku habboon habaynta, kaydinta iyo gaadiidka daroogada. Marka la eego milanka, waxay leedahay milanka dhexdhexaadka ah ee biyaha, iyo deegaanka kala duwan ee acid-saldhigga iyo xaaladaha heerkulka ayaa saameyn doona sifooyinkeeda milanka, taas oo muhiim u ah samaynta daawooyinka, horumarinta foomamka qiyaasta, iyo sida loo hubiyo in lebbiska. kala firdhinta daawooyinka marka la isku duro iyo diyaarinta afka.
Marka la eego waxtarka dawooyinka, Papaverine Hydrochloride waxay ka tirsan tahay fasalka nasashada muruqa siman. Waxay inta badan ka shaqeysaa murqaha siman ee xididdada dhiigga, mareenka caloosha iyo mindhicirka, mareenka biliary-ga iyo qaybaha kale, waxayna kor u qaadaa nasashada muruqa oo siman iyadoo faragelinaysa hababka sida intracellular calcium ion intracellular. Kiliinik ahaan, inta badan waxaa loo isticmaalaa in lagu daaweeyo ischemia ay keento vasospasm, sida madax-xanuun iyo dawakhaad ay keento vasospasm cerebral, taas oo hagaajin karta wareegga dhiigga ee degaanka; Waxa kale oo ay saameyn weyn ku leedahay xanuunka caloosha iyo biliary kolic oo ay keento xinjirowga caloosha iyo mindhicirka, hoos u dhigista xanuunka bukaanka.
Si kastaba ha ahaatee, sida daawooyinka intooda badan, waa muhiim inaad raacdo tilmaamaha dhakhtarkaaga markaad isticmaalayso. Sababo la xiriira shaqooyinka kala duwan ee jireed iyo cudurrada hoose ee bukaannada gaarka ah, dhakhaatiirtu waxay u baahan yihiin inay si buuxda u cabbiraan da'da bukaanka, beerka iyo shaqada kelyaha, daawooyinka kale ee la qaato iyo arrimo kale, oo si sax ah u go'aamiyaan qiyaasta, dariiqa maamulka iyo koorsada daawada, sidaas darteed. si loo hubiyo in daawadu ay tahay mid badbaado leh oo waxtar leh, loogana caawinayo bukaanka inuu soo kabsado. Iyadoo horumarka cilmi-baarista sayniska, cilmi-baarista iyo horumarinta qaababka cusub ee qiyaasta iyo hagaajinta daawooyinka isku dhafan ee ku wareegsan ayaa sidoo kale kululeynaya.