Taleefanka:+86 21 6460 6569
bogga_banner

alaabta

Nicorandil (CAS# 65141-46-0) Sawirka sifaysan
  • Nicorandil (CAS# 65141-46-0) 1

Nicorandil (CAS# 65141-46-0)

Hantida Kiimikada:

Qaanuunka molecular C8H9N3O4
Molar Mass 211.17
Cufnaanta 1.4271 (Qiyaas adag)
Meesha dhalaalaysa 92°C
Boling Point 350.85°C (qiyaasta qallafsan)
Barta Fiishka 230°C
Solubility DMSO:>10 mg/mL. Ku milmay methanol, ethanol, acetone ama glacial acetic acid, wax yar ku milmi kara chloroform ama biyo, ku dhawaad ​​aan lagu milmi karin ether ama benzene.
Uumiga Uumiga 1.58E-08mmHg at 25°C
Muuqashada Caddaan ilaa caddaan u eg budada crystalline
Midabka caddaan ilaa caddaan
Merck 14,6521
Xaalada Kaydinta 2-8°C
Tusmada Dib-u-celinta 1.7400 (qiyaas)
MDL MFCD00186520
Tilmaamaha Jirka iyo Kiimikada Budada crystalline cad, aan ur lahayn ama wax yar ur, qadhaadh. Ku milmay methanol, ethanol, acetone ama acetic acid, wax yar ku milma chloroform ama biyo, qaar yar kuma milmaan ether ama benzene. Barta dhalaalka 88.5-93.5 °c. Sunta daran LD50 jiir (mg/kg): 1200-1300 afka, 800-1000 xididka.
Isticmaal Si looga hortago cudurrada wadnaha, angina pectoris
Barashada in vitro Nicorandil (100 mM) wuxuu kordhay oksaydhka flavoprotein, laakiin ma saamayn xuubabka hadda jira, dib u soo celinta mitoK (ATP) iyo kanaalada dushaK (ATP) ee uruurinta ka sarreeya 10-laab. Nicorandil wuxuu yareeyaa dhimashada unugyada qaabka ischaemic granulation model, saameyn ka hortag ah oo wadnaha ah oo xannibay mitoK (ATP) kanaalka xannibaya 5-hydroxydecanoic acid laakiin maaha dushaK (ATP). Saamaynta kanaalka xannibaya HMR1098. Nicorandil (100 mM) waxay joojisaa luminta TUNEL positivity, cytochrome C translocation, kaspase-3 firfircoonida, iyo awoodda xuubka mitochondrial (Delta (Psi) (m)). Falanqaynta unugyada leh fluorescence Delta (Psi) (m) -tusaha, tetramethylrhodamine ethyl ester (TMRE) by fluorescence activated cell sorter ayaa muujisay in, nicorandil ka hortagtaa Delta (Psi) (m) depolarization ee hab-fiirsashada ku tiirsan (EC (50). ) qiyaastii 40 mM, saturation 100 mm). Labada unug ee la kala qaaday, Nicorandil waxa uu hawl galiyay tabar gudihii dib u hagaajinaya, kanaalka 80 pS K-glibenclamide. Unugyada HEK293T, Nicorandil wuxuu doorbidayaa inuu dhaqaajiyo kanaalka K (ATP) ee ka kooban SUR2B. Nicorandil (100 mM) ayaa si weyn u joojiyay tirada unugyada TUNEL-positive nuclei iyo korodhka 20 mM h2o2-ku-soo-bax-3 hawleed. Nicorandil-fiirsashada-ku-tiirsanaanta waxay ka hortagtaa luminta DeltaPsim ee ay keentay H2O2.
In vivo waxbarasho Nicorandil (2.5 mg / kg maalin kasta, po) oo ay weheliso Amlodipine (5.0 mg / kg maalin kasta, po) saddex maalmood oo ficil ah ayaa si weyn uga hortagay isbeddelada iyo dib u soo celinta dhaqdhaqaaqa enzyme ee heerarka u dhow kuwa jiirka caadiga ah.

Faahfaahinta Alaabta

Tags Product

Calaamadaha halista Xn – Waxyeelo
Xeerarka Khatarta R22 - Waxyeelo leh haddii la liqo
R41 - Khatarta dhaawaca daran ee indhaha
Sharaxaada Badbaadada S26 - Haddii ay dhacdo in indhaha la taabto, isla markiiba ku raaci biyo badan oo raadso talo caafimaad.
S39 - Xidho ilaalinta indhaha / wajiga.
WGK Germany 3
RTECS US4667600
Koodhka HS 29333990
Sunta LD50 ee jiirka (mg/kg): 1200-1300 afka; 800-1000 iv (Nagano)

 

Hordhac

Nicolandil, oo sidoo kale loo yaqaan nicorandil amine, waa iskudhis organic ah. Kuwa soo socdaa waa hordhaca guryaha, adeegsigooda, diyaarinta iyo macluumaadka badbaadada nicorandil:

 

Tayada:

- Nicorandil waa crystalline adag oo aan midab lahayn oo ku milma biyaha iyo dareerayaasha organic.

- Waa iskudhis alkaline ah oo ka falcelin kara acids si ay u soo saaraan iskudhisyada milixda.

- Nicorandil hawadu way xasiloon tahay, laakiin waxa laga yaabaa inay qudhunto marka heerkulku sarreeyo.

 

Isticmaal:

- Nicolandil waxa kale oo loo isticmaali karaa in la isku daro ee kiciya synthesis organic, photosensitizers, iwm.

 

Habka:

Nicolandil waxaa badanaa lagu diyaariyaa falcelinta dimethylamine iyo 2-carbonyl xeryahooda.

- Dareen-celinta waxaa lagu fuliyaa xaaladaha alkaline iyo falcelinta kuleylka waxaa lagu fuliyaa dareere ku habboon.

 

Macluumaadka Badbaadada:

- Nicorandil ilaa xad badbaado ayuu u yahay bini'aadamka marka lagu jiro xaaladaha guud.

- Si kastaba ha ahaatee, waa in taxaddar la sameeyaa si looga fogaado taabashada tooska ah ee indhaha, maqaarka, iyo habka neefsashada.

Xiro qalabka ilaalinta shakhsi ahaaneed ee ku habboon (PPE) sida muraayadaha badbaadada, galoofyada iyo qalabka neefsashada.

- Markaad isticmaalayso ama kaydinayso nicorandil, waa in taxaddar la sameeyaa si looga fogaado shilalka iyo xaaladaha heerkulka sare.

 

  • Kii hore:
  • Xiga:
    • Halkan ku qor fariintaada oo noo soo dir

    alaabta la xidhiidha