N-Fmoc-N'-trityl-L-histidine (CAS# 109425-51-6)
Soo bandhigida N-Fmoc-N'-tryl-L-histidine (CAS # 109425-51-6), dhisme qaali ah oo loogu talagalay isku dhafka peptide kaas oo loogu talagalay in kor loogu qaado cilmi-baaristaada iyo mashaariicda horumarineed. Xaruntan nadiifka ah ee sare waa qalab lagama maarmaan u ah farmashiyeyaasha iyo biochemists kuwaas oo raadinaya inay abuuraan peptides adag oo leh sax iyo hufnaan.
N-Fmoc-N'-trityl-L-histidine waa nooc la ilaaliyo oo ka mid ah amino acid histidine, oo leh labada Fmoc (9-fluorenylmethoxycarbonyl) iyo kooxaha difaaca trityl. Kooxahan ilaalinta ayaa muhiim u ah hubinta xasiloonida iyo falcelinta amino acid inta lagu jiro habka isku-dhafka. Kooxda Fmoc waxay u oggolaaneysaa in si sahlan looga ilaaliyo xaaladaha aasaasiga ah ee fudud, halka kooxda trityl ay bixiso difaac dheeraad ah oo ka dhan ah falcelinta dhinaca aan loo baahnayn, taasoo ka dhigaysa xaruntan mid ku habboon isku-dhafka peptide-wejiga adag (SPPS).
Iyada oo leh qaaciidada molecular ee C30H31N3O2 iyo miisaanka kelli ee 469.59 g/mol, N-Fmoc-N'-tryl-L-histidine waxay soo bandhigaysaa milmayn heer sare ah ee dareerayaasha dabiiciga ah ee caadiga ah, fududaynta ku darida borotokoollada synthetic ee kala duwan. Qaab dhismeedkeeda gaarka ah kaliya ma wanajinayo xasilloonida peptides-ka ka dhasha laakiin sidoo kale waxay gacan ka geysataa dhaqdhaqaaqooda bayooloji, taasoo ka dhigaysa hanti qiimo leh oo daahfurka iyo horumarinta daroogada.
Haddii aad ka shaqaynayso peptides-daweynta, cilmi-baarista bayoolajiga molecular, ama sahaminta waddooyin cusub oo ku saabsan biochemistry, N-Fmoc-N'-tryl-L-histidine waa doorashada ugu habboon ee baahiyahaaga isku-dhafka ah. Alaabtayada waxaa lagu soo saaray iyada oo la raacayo tillaabooyinka xakamaynta tayada adag si loo hubiyo heerka ugu sarreeya ee nadiifnimada iyo joogtaynta, taas oo kuu oggolaanaysa inaad diirada saarto cilmi-baaristaada si kalsooni leh.
Ku darka kartida mashaariicdaada peptide synthesis N-Fmoc-N'-tryl-L-histidine. La kulan faraqa ay reagents tayo sare leh ka samayn karaan shaybaarkaaga maanta!
