N-Boc-N'-tosyl-D-histidine (CAS# 69541-68-0)
Hordhac
Boc-D-His (Tos) -OH (Boc-D-His(Tos) -OH) waa walax kiimiko oo leh sifooyinka soo socda:
Dabeecadda:
1. Muuqashada: caddaan adag
2. formula kelli: C21H25N3O6S
3. Miisaanka kelli: 443.51
4. Barta dhalaalka: qiyaastii 110-115°C
Isticmaal:
Boc-D-His (Tos) -OH waxaa caadi ahaan loo isticmaalaa isku-dhafka organic sida koox ilaalin ah D-histidine (D-His). Isticmaalkeeda ugu weyn waxaa ka mid ah:
1. Marka la isku daro polypeptide, waxaa loo isticmaalaa in lagu sameeyo taxane polypeptide ah oo ay ku jiraan kooxda ilaalinta D-histidine.
2. Waxa loo istcimaalaa dhex dhexaad ka ah maadada kimisteriga daawaynta ee isku xidhka xayndaabyada bartilmaameedka ah.
3. Naqshadeynta iyo isku-dhafka isku-dhafka musharaxiinta daroogada ee cilmi-baarista.
Habka Diyaarinta:
Diyaarinta Boc-D-His (Tos) -OH waxaa badanaa lagu fuliyaa tillaabooyinka soo socda:
1. D-histidine (D-His) waxaa lagu falceliyay p-toluenesulfonyl chloride (p-toluenesulfonyl chloride) si loo siiyo D-histidine p-toluenesulfonyl (D-His-Tos).
2. Xaaladaha alkaline, D-His-Tos waxaa lagu falceliyaa n-butoxycarbonylhydrazine (tert-butyloxycarbonylhydrazide) si loo dhaliyo Boc-D-His (Tos) -OH.
Macluumaadka Badbaadada:
Qiimaynta badbaadada ee Boc-D-His(Tos) -OH waa xadidan tahay, laakiin walxo kiimiko ahaan, tixgalinta badbaadada soo socota waa in la ogaadaa:
1. Iska ilaali neefsashada, taabashada maqaarka iyo indhaha. Xiro qalabka ilaalinta shakhsi ahaaneed ee habboon, sida galoofyada iyo muraayadaha.
2. Waa in la raaco habdhaqanka shaybaadhka wanaagsan marka la isticmaalayo iyo in la hubiyo xaaladaha hawo wanaagsan.
3. Ku kaydi weel xiran, oo ka fog dabka iyo oksidant.
4. Raac xeerarka iyo hab-raacyada ku habboon inta lagu jiro hawsha.
Markaad isticmaalayso Boc-D-His(Tos) -OH, fadlan hubi inaad raacdo xeerarka badbaadada shaybaadhka ee khuseeya iyo tilmaamaha hawlgalka, oo si habboon u kaydi oo u xakamayso kiimikooyinka. Haddii loo baahdo, waxaa lagula talinayaa in lagu shaqeeyo hagida xirfadlayaasha.
