N(alpha) -fmoc-N(epsilon)-(2-chloro-Z)-L-lysine(CAS# 133970-31-7)

Fmoc-(2-chlorobenzyloxycarbonyl) lysine waa soosaar amino acid caadi ah loo isticmaalo oo leh sifooyinka soo socda:1. Muuqaalka: budada crystalline cad;
2. formula kelli: C26H24ClNO5;
3. Miisaanka molecular: 459.92g/mol;
4. Solubility: Ku milmay dareerayaasha organic sida dimethyl sulfoxide (DMSO), dimethyl formamide (DMF), dichloromethane, iwm, oo aan biyo ku milmin;
5. Dhibicda dhalaalka: qiyaastii 170-175 ° C. Isticmaalka aasaasiga ah ee Fmoc- (2-chlorobenzyloxycarbonyl) lysine waa koox ilaalin iyo firfircooni ah oo ku jirta isku-dhafka polypeptides. Kooxdeeda kaarboxyl waa la hawlgelin karaa si ay u sameeyaan ester, ka dibna ay marto falcelinta uumiga leh haraaga amino acid si ay u abuurto silsilad polypeptide ah. Kooxda Fmoc si fudud ayaa looga saari karaa ka dib marka falcelinta la dhammeeyo si loo muujiyo unugyada amino ee la ilaaliyo.

Habka diyaarinta Fmoc-(2-chlorobenzyloxycarbonyl) lysine guud ahaan waxay ku lug leedahay tillaabooyinka soo socda:

1. ka falcelinta lysine N-hydroxybutyrimide (Pbf) si ay u soo bandhigto koox ilaalinaysa;
2. ka falcelinta lysine-Pbf derivative leh 2-chlorobenzyl alkohol si ay u sameeyaan Fmoc-(2-chlorobenzyloxycarbonyl) lysine;
3. Alaabta waxaa lagu soo saaraa dareere ku habboon oo lagu nadiifiyo crystallization si loo helo alaabta saafiga ah.

Marka la eego macluumaadka badbaadada, Fmoc-(2-chlorobenzyloxycarbonyl) lysine waa kiimiko reagen ah waana in la qaado tillaabooyinka badbaadada ku habboon. Qalabka ilaalinta habboon, sida galoofyada shaybaadhka, muraayadaha, iyo dharka shaybaadhka, waa in la xidho inta tijaabada lagu jiro. Iska ilaali inaad neefsato budada ama xalalka, iska ilaali taabashada maqaarka iyo indhaha. Haddii ay dhacdo taabasho shil ah, isla markiiba ku raaci biyo badan oo raadso gargaar caafimaad. Hubi in lagu isticmaalo deegaan shaybaadhka nabdoon oo si sax ah loo kaydiyay si looga hortago shilalka.