Mitotan (CAS# 53-19-0)

Hantida Kiimikada:

Qaanuunka molecular	C14H10Cl4
Molar Mass	320.04
Cufnaanta	1.3118 (Qiyaas adag)
Meesha dhalaalaysa	77-78°C( shid)
Boling Point	405.59°C (qiyaasta qallafsan)
Biyuhu milmayn	<0.1 g/100 ml at 24ºC
Solubility	DMSO: milmay20mg/ml, cad
Muuqashada	budo
Midabka	caddaan ilaa beige
Merck	13,6237 / 13,6237
BRN	2056007
Xaalada Kaydinta	Jawi aan firfircoonayn, Heer kulka qolka
Tusmada Dib-u-celinta	1.6000 (qiyaas)
Tilmaamaha Jirka iyo Kiimikada	Barta dhalaalka 76-78°C biyo ku milma <0.1g/100 mL at 24°C
Isticmaal	Alaabtan waxaa loogu talagalay cilmi-baaris cilmiyeed oo keliya mana loo isticmaali karo ujeedooyin kale.
Barashada in vitro	Xariiqda unugyada TalphaT1 ee jiirka, Mitotane waxay joojisaa muujinta iyo dheecaanka TSH, waxay xannibaysaa jawaabta TSH ilaa TRH, waxayna yaraynaysaa jiritaanka unugyada, waxayna keentaa apoptosis. Unugyada jiirka ee qarsoodiga ah ee TSH-pituitary, Mitotane ma farageliso hoormoonka tayroodhka, laakiin waxay si toos ah u yaraynaysaa dhaqdhaqaaqa sirta ah iyo jiritaanka unugyada. Mitotane wuxuu keenaa necrosis cortical adrenal, dhaawac xuubka mitochondrial, iyo ku xidhidh aan la beddeli karin ee borotiinka CYP. Mitotane (10-40 μm) waxay joojisay dheecaanka cortisol ee basal iyo cAMP laakiin ma keenin dhimashada unugyada. Mitotane waxay muujisay saameyn lid ku ah basal STAAR iyo borotiinnada P450scc. Mitotane (40 μm) ayaa si weyn hoos ugu dhigay heerarka mRNA ee STAR, CYP11A1 iyo cyp21. Mitotane (40 μm) ayaa ku dhawaad si buuxda u baabi'iyay kicinta STAR, CYP11A1, CYP17, iyo CYP21 mRNA by adenosine 8-bromo-cyclic phosphate. Marxaladda S ee unugyada H295R, isku dhafka Mitotane iyo gemcitabine ayaa muujiyay antagonism waxayna faragaliyeen xannibaadda dhexdhexaadinta gemcitabine ee wareegga unugyada.
In vivo waxbarasho	Jiirka, Mitotane (60 mg / kg) ayaa si weyn hoos ugu dhigay mitochondrial adrenal iyo microsomal "P-450" iyo borotiinada microsomal by 34%,55% iyo 35%.

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Faahfaahinta Alaabta

Tags Product

Calaamadaha halista	Xn – Waxyeelo
Xeerarka Khatarta	40 - Caddayn xaddidan ee saamaynta kansarka
Sharaxaada Badbaadada	36/37 - Xidho dhar difaac ku habboon iyo galoofyada.
Aqoonsiga UN-ka	3249
WGK Germany	3
RTECS	KH7880000
Koodhka HS	2903990002
Heerka khatarta	6.1 (b)
Kooxda Baakadaha	III

Hordhac

Mitotane waa unug dabiici ah oo leh magaca kiimikada N, N'-methylene diphenylamine. Kuwa soo socdaa waa hordhaca guryaha, isticmaalkooda, hababka diyaarinta iyo macluumaadka badbaadada mitotane:

Tayada:

- Mitotane waa crystalline adag oo aan midab lahayn kaas oo ku milma dareerayaasha organic sida ethanol, ether, iyo chloroform.

- Mitotane waxay leedahay ur daran.

Isticmaal:

- Mitotane waxaa inta badan loo isticmaalaa isku dhafka falcelinta ee isku dhafka organic waxaana badanaa loo isticmaalaa reagent iyo kicin.

- Waxay ka qaybqaadan kartaa fal-celin kiimikaad oo kala duwan, sida isku-xidhka alkynes, alkylation of compounds caraf udgoon, iwm.

Habka:

- Mitotane waxaa lagu soo saari karaa falcelin laba-tallaabo ah. Formaldehyde waxaa lagu falceliyaa diphenylamine hoos yimaada xaaladaha alkaline si loo sameeyo N-formaldehyde diphenylamine. Kadib, pyrolysis ama falcelinta oksaydhka ee la xakameeyey, waxaa loo beddelaa mitotane.

Macluumaadka Badbaadada:

- Mitotane waa unug cuncun leh mana aha inay si toos ah u taabato maqaarka iyo indhaha. Qalabka ilaalinta habboon sida galoofyada, muraayadaha, iyo dharka ilaalinta waa in la xidho marka la shaqaynayo.

- Markaad kaydinayso oo aad wax ka qabanayso, ka taxadar inaad xidho oo aad ka ilaaliso iftiinka si aad uga fogaato taabsiinta hawada iyo qoyaanka.

- Mitotane waxay ku qudhmisaa heerkulka sare si uu u soo saaro gaas sun ah, ka fogow kuleylinta ama xiriirka walxaha kale ee guban kara.

-Tixraac xeerarka deegaanka oo raac habraacyada hawlgalka badbaadada ee khuseeya marka la tuurayo.

Kii hore: 4- (4-methoxyphenyl) -1-butanol (CAS# 52244-70-9)

Xiga: 2-Chloro-5-aminopyridine (CAS# 5350-93-6)

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