Methyl 2-cyanoisonicotinate (CAS# 94413-64-6)
Khatarta iyo Badbaadada
| Heerka khatarta | 6.1 |
Habka wax soo saarka
Xarunta bartilmaameedka ah waxaa lagu diyaariyay oksaydhyo, amidation iyo fuuqbax leh methyl 2-methyl 4-pyridinecarboxylate (2) oo ah walxaha bilawga ah. qaab dhismeedkeeda waxaa xaqiijiyay 1H NMR iyo MS, wadarta guudna waxsoosaarku wuxuu ahaa 53.0%. Saamaynta saamiga quudinta, heerkulka crystallization, waqtiga falcelinta iyo arrimo kale oo ku saabsan badeecada ayaa lagu bartay tijaabooyin hal-hal-hal ah, iyo xaaladaha habka ayaa la hagaajiyay: n (2): n (potassium permanganate) = 1.0: 2.5, heerkulka crystallization 0 ~ 5 ℃; n (methyl 2-carboxyl -4-pyridinecarboxylate): n (sulfoxide) = 1.0: 1.4, falcelin; falcelinta fuuqbaxa waxay doorataa nidaamka trifluoroacetic anhydride-trietylamine sida wakiilka fuuq-baxa. Nidaamku waa sahlan yahay in la shaqeeyo, xaaladaha falcelintu waa sahlan yihiin, sahlan tahay in kor loo qaado wax soo saarka, oo leh qiime macquul ah oo habboon.
Isticmaal
Tobisostat waxaa loo isticmaalaa in lagu daaweeyo hyperuricemia raaga ee gout. Marka la barbardhigo daawada dhaqameed ee allopurinol (analogi purine), ma saameyn doonto purine iyo pyridine dheef-shiid kiimikaadka iyo dhaqdhaqaaqa enzyme, waxayna hoos u dhigtaa uric acid Saameyntu way ka sii xoog badan tahay, looma baahna maamulka soo noqnoqda ee qiyaasta weyn, iyo badbaadada ayaa ka fiican. Methyl 2-cyano-4-pyridine carboxylate waa walxo ceeriin ah oo muhiim u ah isku dhafka Tobiso.
