L-Pyroglutamic acid CAS 98-79-3
Khatarta iyo Badbaadada
| Calaamadaha halista | Xi - xanaaq |
| Xeerarka Khatarta | 36/37/38 - Cuncun xagga indhaha, habka neefsashada iyo maqaarka. |
| Sharaxaada Badbaadada | S26 - Haddii ay dhacdo in indhaha la taabto, isla markiiba ku raaci biyo badan oo raadso talo caafimaad. S36 - Xidho dhar ilaalin ku habboon. S37/39 - Xidho galoofyada ku haboon iyo ilaalinta indhaha/wejiga |
| WGK Germany | 3 |
| RTECS | TW3710000 |
| FLUKA BRAND F CODES | 21 |
| TSCA | Haa |
| Koodhka HS | 29337900 |
| Hordhac | pyroglutamic acid waa 5-oxyproline. Waxaa lagu sameeyay fuuq-baxa u dhexeeya kooxda α-NH2 iyo kooxda γ-hydroxyl ee glutamic acid si ay u sameeyaan curaarta lactam molecular; Waxa kale oo lagu samayn karaa iyada oo luminta kooxda Amido ee glutamine molecule. Haddii glutathione synthetase yaraanta, waxay keeni kartaa pyroglutamemia, calaamado caafimaad oo taxane ah. Pyroglutamemia waa khalkhal ku yimaada dheef-shiid kiimikaad aashitada organic oo ay sababtay yaraanta glutathione synthetase. Calaamadaha kiliinikada ee dhalashada 12 ~ 24 saacadood bilawga, hemolysis horusocod ah, cagaarshow, Acidosis dheef-shiid kiimikaad joogto ah, xanuunada maskaxda, iwm.; Kaadida waxaa ku jira pyroglutamic acid, lactic acid, Alpha deoxy4 glycoloacetic acid lipid. Daaweynta, calaamadaha, fiiro gaar ah u yeelo cuntada ka dib da'da. |
| guryaha | L-pyroglutamic acid, oo sidoo kale loo yaqaan L-pyroglutamic acid, L-pyroglutamic acid. Laga soo bilaabo ethanol iyo isku dhafka ether petroleum ee roobka orthorhombic double cone Crystal, barta dhalaalaysa ee 162 ~ 163 ℃. Ku milmay biyaha, khamriga, acetone iyo acetic acid, ethyl acetate-soluble, aan milmin ee etherka. Wareegga indhaha ee gaarka ah -11.9 °(c = 2,H2O). |
| Tilmaamaha iyo isticmaalka | Maqaarka bini'aadamka wuxuu ka kooban yahay shaqada qoyaanka ee walxaha biyaha ku milma - factor huurka dabiiciga ah, ka kooban yahay qiyaastii amino acid (oo ka kooban 40%), pyroglutamic acid (oo ka kooban 12%), cusbada aan organic (Na, K, Ca, Mg, iwm). oo ka kooban 18.5%), iyo xeryahooda kale ee organic (oo ka kooban 29.5%). Sidaa darteed, pyroglutamic acid waa mid ka mid ah qaybaha ugu muhiimsan ee maqaarka qoyaanka dabiiciga ah, iyo awooddeeda qoyaanku aad uga badan tahay glycerol iyo propylene glycol. Oo aan sun ahayn, wax kicin ah, waa Daryeelka Maqaarka ee casriga ah, Qurxinta Daryeelka timaha alaabta ceeriin ee aad u fiican. Pyroglutamic acid sidoo kale waxay saameyn ku leedahay waxqabadka tyrosine oxidase, taas oo ka hortagaysa soo-saarka walxaha "melanoid" ee maqaarka, taas oo saameyn ku leh maqaarka. Waxay saameyn jilicsan ku leedahay maqaarka, waxaa loo isticmaali karaa qurxinta ciddiyaha. Marka lagu daro codsiga qurxinta, L-pyroglutamic acid waxay sidoo kale soo saari kartaa derivatives leh xeryahooda kale ee organic, kuwaas oo saameyn gaar ah ku leh dhaqdhaqaaqa dusha sare, saameyn hufan oo dhalaalaya, iwm. Waxa kale oo loo isticmaali karaa sida surfactant ee saabuunta; Kiimikada reagen ee xallinta aminyada jinsiyadeed; Dhexdhexaadiyeyaasha dabiiciga ah. |
| habka diyaarinta | L-pyroglutamic acid waxaa la sameeyay iyadoo laga saarayo hal daqiiqo oo biyo ah molecule of L-glutamic acid, iyo habka diyaarintiisa waa mid fudud, tillaabooyinka muhiimka ah waa xakameynta heerkulka iyo waqtiga biyaha. (1) 500g oo L-glutamic acid ah ayaa lagu daray 100 litir oo biyo ah, waxaana lagu kululeeyay saliidda qubeyska, heerkulkuna wuxuu gaadhay 145 ilaa 150 ° C., heerkulkuna wuxuu ahaa 45 daqiiqo fuuqbax. falcelin. Xalka fuuqbaxa wuxuu ahaa Tan. (2) ka dib marka la dhammeeyo falcelinta fuuq-baxa, xalka waxaa lagu shubay biyo karkaraya oo leh mugga qiyaastii 350, iyo xalku si buuxda ayaa loogu milmay biyaha. Ka dib qaboojinta ilaa 40 ilaa 50 ° C., qadar habboon oo kaarboon firfircoon ah ayaa lagu daray midabaynta (laba jeer oo soo noqnoqda). Xal hufan oo aan midab lahayn ayaa la helay. (3) marka xalka hufan ee aan midab lahayn ee loo diyaariyey tallaabada (2) si toos ah loo kululeeyo oo loo uumi baxo si loo yareeyo mugga ilaa kala badh, u rog biyaha qubeyska oo sii wad inaad xoogga saarto mugga qiyaastii 1/3, waxaad joojin kartaa kuleylka, iyo qubeyska biyaha kulul si loo yareeyo crystallization, 10 ilaa 20 saacadood ka dib diyaarinta crystals prismatic aan midab lahayn. Qadarka L-pyroglutamic acid ee alaabta la isku qurxiyo waxay kuxirantahay diyaarinta. Alaabtan waxa kale oo loo isticmaali karaa waxyaabaha la isku qurxiyo ee qaabka 50% xalalka la isku koobay. |
| glutamic acid | glutamic acid waa amino acid ka kooban borotiin, waxa uu leeyahay silsilad dhinaca aashitada ionized, oo muujinaysa hydrotropism. Glutamic acid waxay u nuglaysaa wareegga wareegga ee pyrrolidone carboxylic acid, I .e., pyroglutamic acid. glutamic acid ayaa si gaar ah ugu sarreeya dhammaan borotiinnada badarka, taasoo bixisa alfa-ketoglutarate iyada oo loo marayo wareegga tricarboxylic acid. Alfa ketoglutaric acid si toos ah ayaa looga soo saari karaa ammonia iyada oo hoos timaada catalysis of glutamate dehydrogenase iyo NADPH (coenzyme II), sidoo kale waxaa lagu kicin karaa aspartate aminotransferase ama alanine aminotransferase, glutamic acid waxaa lagu soo saaraa transamination of aspartic acid ama alanine; Intaa waxaa dheer, glutamic acid waxaa lagu beddeli karaa proline iyo ornithine (laga bilaabo arginine), siday u kala horreeyaan. Sidaa darteed Glutamate waa amino acid nafaqo ahaan aan muhiim ahayn. Marka glutamic acid la demiyo iyada oo hoos timaada catalysis of glutamate dehydrogenase iyo NAD (coenzyme I) ama laga wareejiyo kooxda amino hoos yimaada catalysis of aspartate aminotransferase ama alanine aminotransferase si loo soo saaro alfa ketoglutarate, waxay gashaa wareegga tricarboxylic acid waxayna soo saartaa sonkor iyada oo loo marayo Jidka gluconeogenic, sidaa darteed glutamic acid waa amino acid glycogenic muhiim ah. glutamic acid ee unugyo kala duwan (sida muruqa, beerka, maskaxda, iwm.) waxay ku dhex samaysan kartaa glutamine NH3 iyada oo loo marayo catalysis of glutamine synthetase, waa sheyga sun-saarista ee ammonia, gaar ahaan unugyada maskaxda, iyo sidoo kale qaabka kaydinta iyo isticmaalka ammonia ee jirka (eeg "glutamine iyo dheef-shiid kiimikaad"). Acid glutamic waxaa lagu farsameeyaa acetyl-CoA sida cofactor of mitochondrial carbamoyl phosphate synthase (ku lug leh isku dhafka urea) iyada oo loo marayo kicinta acetyl-glutamate synthase. γ-aminobutyric acid (GABA) waa wax soo saarka decarboxylation of glutamic acid, gaar ahaan in uruurinta sare ee unugyada maskaxda, iyo sidoo kale ka muuqataa in dhiigga, shaqadeeda jireed waxaa loo arkaa in ay inhibitory neurotransmitter, antispasmodic ah iyo saamaynta hypnotic ee ay sameeyeen faleebo kiliinikada ah ee echinocandin ayaa laga yaabaa in lagu gaaro GABA. Catabolism-ka GABA wuxuu galaa wareegga tricarboxylic acid isagoo u beddelaya GABA transaminase iyo aldehyde dehydrogenase galay succinic acid si ay u sameeyaan shunt GABA ah. |
| Isticmaal | loo isticmaalo dhex-dhexaadinta isku-dhafka dabiiciga ah, cuntada lagu daro, iwm. loo isticmaalo cuntada,daawoyinka, qurxinta iyo warshadaha kale |
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