Fmoc-O-tryl-L-serine (CAS# 111061-56-4)
Soo bandhigida Fmoc-O-trityl-L-serine (CAS # 111061-56-4), Dhisme qaali ah oo loogu talagalay isku-darka peptide kaas oo loogu talagalay in kor loogu qaado cilmi-baaristaada iyo mashaariicda horumarineed ee heerar cusub. Xaruntan nadiifka ah ee sare waxay lagama maarmaan u tahay farmashiyeyaasha iyo biochemists ee raadinaya inay abuuraan peptides adag oo sax ah iyo hufnaan.
Fmoc-O-trtyl-L-serine waa nooc la ilaaliyo oo ah serine amino acid, oo leh isku darka gaarka ah ee Fmoc (9-fluorenylmethoxycarbonyl) iyo trityl (Tr) kooxaha ilaalinta. Istaraatiijiyadan ilaalinta laba-geesoodka ah kaliya ma wanajinayso xasilloonida haraaga serine inta lagu guda jiro isku-duubnida laakiin sidoo kale waxay ogolaataa ilaalinta xulashada, taasoo ka dhigaysa doorasho ku habboon isku-dhafka peptide-wejiga adag (SPPS). Kooxda Fmoc waxay fududaynaysaa ka saarista fudud ee xaaladaha aasaasiga ah ee fudud, halka kooxda trityl ay bixiso difaac dheeraad ah oo ka dhan ah falcelinta dhinaca aan loo baahnayn.
Iyada oo leh caanaha molecular ee C27H29NO4 iyo miisaanka molecular ee 433.53 g / mol, Fmoc-O-trtyl-L-serine waxaa lagu gartaa milanka sare ee dareeraha organic, taas oo ka dhigaysa mid ku habboon codsiyada synthetic ee kala duwan. Nadiifinteeda gaarka ah waxay hubinaysaa in alaabtaada peptide-ka ee ugu dambeeya ay yihiin kuwa ugu tayada sarreeya, oo ka nadiif ah wasakh wax u dhimi kara natiijooyinkaaga cilmi-baarista.
Haddii aad horumarinayso peptides-ka-daweynta, baranaya isdhexgalka borotiinka, ama sahaminta musharraxiinta daroogada cusub, Fmoc-O-trityl-L-serine waa doorashada lagu kalsoonaan karo ee baahiyahaaga isku-dhafka ah. Alaabtayadu si adag ayaa loo tijaabiyay oo waxay la socotaa dukumeenti dhammaystiran si ay u taageeraan dadaalkaaga cilmi-baarista.
Ku fur awoodda isku-dhafka peptide-kaaga Fmoc-O-tryl-L-serine. La kulan faraqa ay reagents tayo sare leh ka samayn karaan shaybaarkaaga. Hadda dalbo oo qaado tallaabada ugu horreysa si aad u gaartid yoolalkaaga cilmiyeed si kalsooni leh!
