fmoc-O-tert-butyl-D-tyrosine (CAS# 118488-18-9)
Fmoc-O-tert-butyl-D-tyrosine waa amino acid inta badan la isticmaalo. Kuwa soo socda waa sharaxaadda dabeecadeeda, isticmaalkeeda, habaynteeda iyo macluumaadka badbaadada:
Dabeecadda:
Fmoc-O-tert-butyl-D-tyrosine waa crystalline cad oo adag. Waa iskudhis dabiici ah oo leh qaacidada kiimikada C30H31NO7 iyo miisaan kelli ah 521.57g/mol. Iskudhisku waa nooc ka mid ah tyrosine-ka kaas oo kooxda amino-ku sido kooxda ilaalinta Fmoc (9-fluorofluorenylformyl) iyo kooxda karboksylic acid waxaa lagu nadiifiyaa O-tert-butyl.
Isticmaal:
Fmoc-O-tert-butyl-D-tyrosine waxaa caadi ahaan loo isticmaalaa sidii amino acid ilaalin ah ee isku-dhafka peptide. Markaad ku dhejiso kooxda ilaalinta Fmoc ee kooxda amino, falcelinta aan la rabin ayaa laga hortagi karaa inta lagu jiro isku-dhafka. Waxaa si ballaaran loo adeegsadaa isku-dhafka wajiga adag waxaana loo isticmaali karaa in lagu sameeyo polypeptides iyo borotiinada.
Habka Diyaarinta:
Diyaarinta Fmoc-O-tert-butyl-D-tyrosine waxaa guud ahaan lagu sameeyaa isku-dhafka kiimikada. Marka hore, tyrosine waxaa lagu falceliyaa Fmoc-Cl (9-fluorofluorenylcarbonyl chloride) si loo soo saaro Fmoc-O-tyrosine. Cesium tert-butyl bromide ayaa markaa lagu daraa falcelinta si loo caddeeyo kooxda karboxilic acid si ay u sameeyaan Fmoc-O-tert-butyl-D-tyrosine. Ugu dambeyntii, badeecada saafiga ah waxaa lagu helaa tallaabooyinka crystallization, dhaqidda iyo qalajinta.
Macluumaadka Badbaadada:
Fmoc-O-tert-butyl-D-tyrosine waa xarun deggan oo ku jirta xaaladaha caadiga ah mana laha isbedel muuqda heerkulka qolka. Inta lagu jiro isticmaalka, waxaa lagama maarmaan ah in loo hoggaansamo hababka badbaadada shaybaarka, xidho qalab ilaalin habboon, lagana fogaado taabashada maqaarka iyo indhaha. Marka la maaraynayo ama la kaydinayo, waa in lagu hayaa meel qalalan, qabow oo ka fog dabka iyo walxaha oksaydhka. Isla mar ahaantaana, xiriirka oksidants xooggan iyo asiidhyada xooggan waa in laga fogaadaa si looga hortago falcelinta khatarta ah. Raadso gargaar caafimaad oo degdeg ah haddii aad si lama filaan ah u soo gaadhay xarunta.
