FMOC-Arg(Pbf) -OH (CAS# 154445-77-9)
Khatarta iyo Badbaadada
| Calaamadaha halista | Xi - xanaaq |
| Xeerarka Khatarta | 36/37/38 - Cuncun xagga indhaha, habka neefsashada iyo maqaarka. |
| Sharaxaada Badbaadada | S26 - Haddii ay dhacdo in indhaha la taabto, isla markiiba ku raaci biyo badan oo raadso talo caafimaad. S36 - Xidho dhar ilaalin ku habboon. |
| WGK Germany | 1 |
| Koodhka HS | 2935 90 90 |
| Heerka khatarta | XANUUNSAN |
Hordhac
Kooxda-ilaalinta FMOC waa koox ilaalinta amino acid caadi ahaan loo isticmaalo oo ilaalisa kooxda shaqada amino ee arginine. Kuwa soo socdaa waa horudhac ku saabsan qaar ka mid ah guryaha, adeegsiyada, hababka diyaarinta, iyo macluumaadka badbaadada ee Radical-ilaalinta Fmoc:
Tayada:
Kooxda ilaalinta FMOC waa koox ilaalin la saari karo oo ilaaliya kooxaha amino-amino. Waxay la falcelin kartaa kooxda amino ee arginine iyada oo loo marayo falcelinta esterification si loo sameeyo Fmoc-arginine ester, si loo gaaro ujeedada ilaalinta kooxda amino. Waxaa jira kooxo udgoon oo ku jira molecule-koox-difaaca Fmoc kuwaas oo si xoog leh u nuugaya iftiinka UV, kaas oo u oggolaanaya ka saarista kooxda ilaalinta Fmoc in lagu fuliyo shucaaca UV ama hababka kiimikada.
Isticmaal:
Kooxaha ilaalinaya FMOC ayaa si weyn loogu isticmaalaa isku-dhafka peptide iyo isku-dhafka wejiga adag. Waxay si wax ku ool ah u ilaalin kartaa kooxda amino ee arginine si ay uga hortagto falcelinta dhinaceeda inta lagu jiro isku-dhafka. Isku-dhafka peptide, kooxda Fmoc-ilaalinta ayaa laga saari karaa xaaladaha alkaline, taas oo u oggolaanaysa isku-dhafka polypeptides inuu sii socdo.
Habka:
Kooxda Fmoc-ilaalinta waxaa lagu diyaarin karaa falcelinta Fmoc-Cl iyo arginine. Fmoc-Cl waa reagent xoog leh oo acidic ah oo la falgala kooxda amino ee arginine si ay u sameeyaan Fmoc-arginine ester. Dareen-celinta waxaa badanaa lagu sameeyaa ethanol heerkulka qolka ilaa heerkulka qubayska barafka.
Macluumaadka Badbaadada:
FMOC-Protective Radicals waa badbaado in lagu isticmaalo xaaladaha shaybaadhka caadiga ah, laakiin kuwa soo socda waa in la ogaadaa:
- FMOC-CL waa cuncun iyo walax sun ah, taxaddar waa in la qaataa si looga fogaado taabashada maqaarka, neefsashada ama qaadashada. Ka shaqee meel hawo fiican leh oo xidho qalabka ilaalinta shakhsi ahaaneed ee habboon.
-Foc-Protective Base waxay leedahay hanti nuugista xooggan ee fallaadhaha ultraviolet, markaa waa in laga taxadaraa si looga hortago taabashada tooska ah ee maqaarka iyo indhaha inta lagu jiro isticmaalka, lagana fogaado ilaha iftiinka xooggan.
- Ilaalinta aashitada adag ee hydrolysis sida pentafluorophenylcarboxylic acid (TFA) ayaa badanaa la isticmaalaa inta lagu jiro ka saarida kooxaha Fmoc-protective, waxaana lagama maarmaan ah in la ogaado in uumiga TFA uu keeni karo dhaawac, sidaas darteed waa lagama maarmaan in si fiican loo shaqeeyo. aagga hawo leh.
