Ethyl 1- (4-methoxyphenyl) -6- (4-aminophenyl) -7-oxo-4 5 6 7-tetrahydro-1H-pyrazolo [3 4-c] pyridine-3-carboxylate (CAS # 503615-07-4) )

Hordhac

Kuwa soo socdaa waa horudhac ku saabsan guryaha, isticmaalkooda, hababka diyaarinta iyo macluumaadka badbaadada apixaban dhexe 3:

Tayada:

Apixaban intermediate 3 waa iskudhis organic ah. Waa mid adag oo ku milma dareerayaasha organic sida ether iyo ethyl acetate.

Isticmaala: Waxaa caadi ahaan loo isticmaalaa suuxinta qaliinka iyo daaweynta xanuunka daran.

Habka:

Habka diyaarinta ee apixaban dhexdhexaad ah 3 waxaa lagu fulin karaa tallaabooyinka soo socda: p-nitrobenzoic acid waxaa lagu falceliyaa hypobutylthiourea ee wada jir ah acetic acid iyo thionyl chloride si loo helo N- (p-nitrophenyl) -N- (hypobutylthioylurea) formic acid, ka dibna, la falgaliyay sodium hydroxide ee sodium oxide iyo xal methanol si loo helo apixaban dhexe 3.

Macluumaadka Badbaadada: Nidaamyada hawlgalka ee badbaadada adag ayaa loo baahan yahay in la raaco marka la isticmaalayo iyo la tacaalida xaruntan. Xidhiidhka tooska ah ama neefsashada ayaa sababi karta dhaawac halis ah caafimaadka aadanaha. Macluumaadkeeda gaarka ah ee badbaadada waa in la qiimeeyaa oo laga baaraandegaa si waafaqsan xeerarka iyo habraacyada khuseeya si loo hubiyo isticmaalka iyo maaraynta badbaadada leh. Marka la samaynayo tijaabooyinka isku dhafka kiimikaad, waa in lagu shaqeeyaa xaaladaha shaybaadhka ku habboon waana in la isticmaalo qalabka ilaalinta shakhsi ahaaneed sida muraayadaha kiimikaad, galoofyada ilaalinta, iyo dharka ilaalinta.