Cbz-L-Glutamic acid 1-benzyl ester (CAS# 3705-42-8)

Hordhac

Z-Glu-OBzl (Z-Glu-OBzl) waa unug dabiici ah oo inta badan loo isticmaalo sidii koox ilaalinaysa asiidhyada amino. Kuwa soo socda waa sharaxaadda guryaha, isticmaalkooda, diyaarinta iyo macluumaadka badbaadada xarunta:

Dabeecadda:

-Qaabka molecular: C17H17NO4

-Miisaanka molecular: 303.32g/mol

-Muuqaalka: Budada crystalline cad

-Dalka dhalaalay: 84-85°C

-Solubility: Ku milmay dareerayaasha organic sida dimethyl sulfoxide iyo dimethylformamide

- Kooxda ilaalinta Cbz waxaa ka saari kara palladium hydride kicinta xaaladaha acidic

Isticmaal:

- Z-Glu-OBzl waa koox ilaalinaysa glutamic acid (Glu), kaas oo loo isticmaali karo isku dhafka amino acid derivatives, polypeptides iyo borotiinada.

Sida kooxda ilaalinta amino acids ee xeryahooda organic synthetic, waxay ilaalin kartaa kooxda amin ee glutamic acid, waxay ka ilaalin kartaa inay saameyn ku yeelato falcelinta aan gaarka ahayn, waxayna fududeyn kartaa saarista marka loo baahdo.

Habka Diyaarinta:

-Diyaarinta Z-Glu-OBzl inta badan waxaa ku jira hannaan dhowr tallaabo ah oo ku lug leh falcelin kiimiko oo taxane ah. Mid ka mid ah hababka caadiga ah waa in marka hore la ilaaliyo kooxda karboxyl ee glutamic acid sida t-butoxycarbonyl ester (Boc) ka dibna la ilaaliyo kooxda amino sida Cbz. Ugu dambeyntii, badeecada la doonayo Z-Glu-OBzl waxaa lagu sameeyay falcelin leh chloroformate benzyl.

Macluumaadka Badbaadada:

- Z-Glu-OBzl waa in loola dhaqmaa sidii isku-dhisyo cuncun leh kana fogow taabashada tooska ah ee maqaarka iyo indhaha.

-Marka shaybaadhka lagu isticmaalo, waa in la raaco hababka badbaadada saxda ah, oo ay ku jiraan xidhashada muraayadaha difaaca, galoofyada iyo jaakadaha shaybaadhka.

-Waa in laga fogaadaa in la neefsado ama la dhuuqo xarunta, lagana hortago dabka iyo qaraxyada inta lagu jiro kaydinta.

-Xaruntu waa in la geliyo jawi hawo fiican leh inta lagu guda jiro hawsha, iyo in si habboon loo asturo qashinka iyadoo la raacayo xeerarka deegaanka.