5-Fluorocytosine (CAS# 2022-85-7)
Khatarta iyo Badbaadada
| Xeerarka Khatarta | R40 - Caddayn xaddidan ee saamaynta kansarka R36/37/38 - Waxay ka xanaajisaa indhaha, habka neefsashada iyo maqaarka. R63 - Khatarta suurtagalka ah ee waxyeellada ilmaha caloosha ku jira |
| Sharaxaada Badbaadada | S22 - Ha neefsan boorka. S24/25 - Iska ilaali taabashada maqaarka iyo indhaha. S45 - Haddii ay dhacdo shil ama haddii aad dareento xanuun, raadso talo caafimaad isla markiiba (tus calaamadda mar kasta oo ay suurtagal tahay.) S36/37 - Xidho dhar difaac ku haboon iyo galoofyada. S36/37/39 - Xidho dhar ilaalin ku haboon, galoofyada iyo ilaalinta indhaha/wejiga. S27 - Isla markiiba iska siib dhammaan dharka wasakhaysan. S26 - Haddii ay dhacdo in indhaha la taabto, isla markiiba ku raaci biyo badan oo raadso talo caafimaad. |
| WGK Germany | 2 |
| RTECS | HA6040000 |
| FLUKA BRAND F CODES | 10-23 |
| Koodhka HS | 29335990 |
| Xusuusin Khatarta | Sunta/Iftiinka xasaasiga ah |
| Heerka khatarta | XANUUNKA, DAREENKA FUDUD |
| Sunta | LD50 ee jiirarka (mg/kg): >2000 af iyo sc; 1190 ip; 500 iv (Grunberg, 1963) |
5-Fluorocytosine (CAS# 2022-85-7) Hordhac
tayada
Alaabtani waa budo crystalline ah oo cad ama ka baxsan, oo aan ur lahayn ama wax yar ur ah. In yar oo biyo ah, milmayn 1.2% at 20 °C biyaha, wax yar ku milmay ethanol; Waxay ku dhowdahay inaan lagu milmi karin chloroform iyo ether; Ku milmay acid hydrochloric ama milanka sodium hydroxide. Waxay ku xasiloon tahay heerkulka qolka, soo daadi crystals marka qabow, iyo qayb yar ayaa loo beddelaa 5-fluorouracil marka la kululeeyo.
Alaabtani waa daawada fangas-ka-hortagga ah ee la sameeyay 1957 waxaana loo adeegsaday waxqabadka kiliinikada 1969, oo leh saameyn cad oo bakteeriyada bakteeriyada Candida, cryptococcus, fangaska midabaynta iyo Aspergillus, oo aan wax saameyn ah ku lahayn fangaska kale.
Saamaynta ay ku leedahay fangaska ayaa sabab u ah gelitaanka unugyada fangaska xasaasiga ah, halkaas oo hoos yimaada ficilka nucleopyine deaminase, ka saara kooxaha amino si ay u sameeyaan antimetabolite-5-fluorouracil. Midda dambe ayaa loo beddelaa 5-fluorouracil deoxynucleoside waxayna joojisaa thymine nucleoside synthetase, waxay xannibaysaa beddelka uracil deoxynucleoside ee thymine nucleoside, waxayna saamaysaa isku-dhafka DNA-da.
isticmaal
Antifungals Waxaa inta badan loo isticmaalaa candidiasis xuubka, candiddal endocarditis, candid art arthritis, cryptococcal meningitis iyo koromomycosis.
Isticmaalka iyo qiyaasta afka, 4 ~ 6g maalintii, loo qaybiyey 4 jeer.
amniga
Tirada dhiigga waa in si joogto ah loo fiiriyaa inta lagu jiro maamulka. Bukaanka qaba beerka iyo kelyaha oo aan ku filneyn iyo cudurrada dhiigga iyo haweenka uurka leh waa inay si taxadar leh u isticmaalaan; Kahortagga bukaanka qaba kelyo-yarida daran.
Hadhka, kaydinta hawo-mareenka.
