5-Bromo-3-nitro-2-pyridinol (CAS# 15862-34-7)
Khatarta iyo Badbaadada
| Xeerarka Khatarta | R22 - Waxyeelo leh haddii la liqo R37/38 - Ka xanaajiso habka neefsashada iyo maqaarka. R41 - Khatarta dhaawaca daran ee indhaha R36/37/38 - Waxay ka xanaajisaa indhaha, habka neefsashada iyo maqaarka. R20 – Waxyeello bay u leedahay neefsashada |
| Sharaxaada Badbaadada | S26 - Haddii ay dhacdo in indhaha la taabto, isla markiiba ku raaci biyo badan oo raadso talo caafimaad. S36/37/39 - Xidho dhar ilaalin ku haboon, galoofyada iyo ilaalinta indhaha/wejiga. S36 - Xidho dhar ilaalin ku habboon. |
| Aqoonsiga UN-ka | 2811 |
| WGK Germany | 3 |
| Koodhka HS | 29337900 |
| Xusuusin Khatarta | Waxyeelo leh |
| Heerka khatarta | XANUUNSAN |
Macluumaadka Tixraaca
| Isticmaal | 5-bromo-2-hydroxy-3-nitropyridine waa dhexdhexaad dabiici ah oo loo isticmaali karo in lagu diyaariyo xeryahooda 3-amino-1- (2-oxo-2-----3-- (trifluoromethyl) -[1,1'-biphenyl ] -4-yl) ethyl)-5-(pyrrole alkyl-1-yl-sulfonyl) pyridin-2 (1H) -kow, xaruntani waa isku-xidhka xannibaadda ee DOCK1. |
| habka synthesis | nitric acid (60-61%,3.5mL) ayaa lagu daray xalka (10mL) ee 5-bromopyridine -2(1H) -hal (1.75g,10.1mmol) ee sulfuric acid at 0 ℃. Isku dar ah ayaa loo oggol yahay in lagu kululeeyo heerkulka qolka oo walaaq ilaa 3 saacadood. Isku darka falcelinta waxaa lagu shubaa biyo baraf ah waxaana lagu soo ururiyaa sifeynta. Badeecada ka soo baxday waxaa lagu dhaqay biyo waxaana lagu qallajiyey faakuum, siinta 5-bromo-2-hydroxy-3-nitropyridine (960mg, 43% dhalidda) sida adag cad. 1H NMR(500MHz,CDCl3)δ:8.57(s,1H),8.26(s,1H). |
Halkan ku qor fariintaada oo noo soo dir
