4-Bromo-3-fluorobenzoic acid (CAS# 153556-42-4)
Macluumaadka Tixraaca
| Adeegsada | 4-bromo-3-fluorobenzoic acid waa walxo kiimiko ah oo ceeriin ah oo muhiim ah oo loo isticmaali karo in lagu diyaariyo daawooyin kala duwan (sida daawada anti-kansarka ee benzamit). |
| Habka synthesis | 4-bromo-3-fluorobenzoic acid waxaa lagu heli karaa oksaydheynta 4-bromo-3-fluorotoluene iyada oo loo marayo potassium permanganate. (1) oksaydhaynta: 100kg ee kg4-bromo -3-fluorotoluene, 120kg oo biyo ah iyo 0.1kg ee khamriga dufanka leh polyether sodium sulfate (AES) ayaa si isdaba joog ah loogu daray K-400L weelka falcelinta galaas-ku dahaadhay (oo ay soo saartay Jiangsu Equipment Co., Ltd.) oo leh kicinta iyo kuleylinta iyo qalabka reflux-ka, ka dibna 167kg oo ah potassium permanganate ayaa si tartiib tartiib ah loogu daraa xaalad walaaqaya, lagu hayo xaalad karkaraya, oo ka falcelisa 9 saacadood, jooji falcelinta ka dib markii xalka reflux uusan haysanin saliidda; (2) Shaandhaynta: miir xalalka falcelinta ee lagu helay tallaabada (1) iyadoo kulul si aad u hesho shaandhada ka kooban badeecada la beegsanayo 4-bromo -3-fluorobenzoic acid; (3) Ka saar permanganate potassium: Si looga saaro inta soo hartay ee potassium permanganate ee sifaynta, 0.1kg ee sodium sulfite waa in lagu daraa sifaynta la helay tallaabada (2), qadarka dheeriga ah ee sodium sulfite waxay ku salaysan tahay dareeraha hufan midabka guduudan ee xalka. (4) aashitada: xaaladda walaaqaya, si tartiib ah ugu dar walaxda xalka lagu helay tallaabada (3) oo leh 12mol/L oo uruursan hydrochloric acid. marka qiimaha pH ee xalku yahay 2.2, jooji ku darista hydrochloric acid oo sii wad falcelinta 30min. (5) crystallization: xaaladda kicinta, xalalka laga helay tallaabada (4) ayaa la qaboojiyey ilaa 2 ° C, iyo kiriimyada ku da'ay xalka waa 4-bromo-3-fluorobenzoic acid. Inta lagu jiro qalliinka, waa in si joogto ah loo walaaqaa, haddii kale 4-bromo-3-fluorobenzoic acid waxay sameyn doontaa adag weyn, taas oo ay adag tahay in wax laga qabto hababka xiga; (6) Shaandhaynta iyo dhaqidda: Dareeraha isku dhafan ee ka kooban 4-bromo-3-fluorobenzoic acid crystals ee lagu helay tallaabada (5) ayaa la xoojiyay si loo helo keega filter kaas oo ah sheyga 4-bromo-3-fluorobenzoic acid, alaabta ceeriin. waxaa lagu dhaqaa biyo saafi ah oo la centrifuge (iyadoo la isticmaalayo centrifuge leh hawl dhaqid) si loo helo sifaysan 4-bromo-3-fluorobenzoic acid; (7) Qalajinta: 4-bromo-3-fluorobenzoic acid adag oo lagu diyaariyey tallaabada (6) ayaa lagu qallajin karaa 75 ° C 12 saacadood si loo helo 197 kg4-bromo-3-fluorobenzoic acid, nuxurka kaas oo ka weyn 98 %. |
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