2,4,5-Trifluorophenylacetic Acid (CAS# 209995-38-0)
Codsiga
2,4, 5-trifluorophenylacetic acid waa cad adag oo loo isticmaalo in lagu sameeyo dawada cusub ee sitagliptin dhexdhexaadiyaha daaweynta nooca II ee sonkorowga. sitagliptin waa horjoogaha ugu horreeya ee DPP-IV oo ay dhawaan liis garaysay Merck. Waxay leedahay saameyn daawaynta wanaagsan, waxyeellooyin yaryar, badbaado wanaagsan iyo dulqaad daawaynta nooca II ee sonkorowga, waxayna leedahay rajooyin suuqa oo ballaaran.
Tilmaamid
Muuqaalka Crystallization
Midabka Caddaan ilaa Cadaan
pKa 3.78± 0.10 (La saadaaliyay)
Xaalada Kaydinta Waxaa lagu xidhay qalalan, heerkulka qolka
Tusmada dib-u-celinta 1.488
Badbaadada
Calaamadaha halista Xi - xanaaq badan
Xanaaqsan
Xeerarka Khatarta R37/38 - Ka xanaajiso habka neefsashada iyo maqaarka.
R41 - Khatarta dhaawaca daran ee indhaha
Sharaxaada Badbaadada S26 - Haddii ay dhacdo in indhaha la taabto, isla markiiba ku raaci biyo badan oo raadso talo caafimaad.
S39 - Xidho ilaalinta indhaha / wajiga.
WGK Germany 3
HS code 29163990
Heerka Khatarta IRRATANT
Baakaynta & Kaydinta
Waxaa lagu soo raray 25kg/50kg. Ku hay meel mugdi ah, ku xidhan meel engegan, heerkulka qolka
Hordhac
Soo bandhigida 2,4,5-Trifluorophenylacetic Acid, adag cad oo si weyn loogu isticmaalo warshadaha dawooyinka si loogu sameeyo dhexdhexaadiyaha sitagliptin ee daaweynta nooca II ee sonkorowga.
Iyada oo qayb muhiim ah ka ah soo saarista sitagliptin, 2,4,5-Trifluorophenylacetic Acid waxay door muhiim ah ka ciyaartay horumarinta daawadan aadka waxtarka leh. Sitagliptin waa xakameyntii DPP-IV ee ugu dambeysay oo ay dhawaan liis gareysay Merck. Waxay ku faantaa saamaynta daawaynta aad u wanaagsan, waxyeelada ugu yar, badbaadada iyo dulqaadka, waxayna noqotay daawo loo tago daawaynta nooca II ee sonkorowga.
Mid ka mid ah faa'iidooyinka muhiimka ah ee 2,4,5-Trifluorophenylacetic Acid waa in ay suurtageliso soo saarista sitagliptin qiimo jaban, taas oo u oggolaanaysa shakhsiyaad badan inay helaan dawadan wax ka beddeleysa nolosha. Intaa waxaa dheer, aad bay waxtar ugu leedahay daawaynta cudurka macaanka waxayna siisaa rajo cusub kuwa la halgamaya xaaladda.
Muuqashada 2,4,5-Trifluorophenylacetic Acid waa crystalline cad oo ka baxsan budo cad, taas oo fududaynaysa in la aqoonsado, gacanta, iyo gaadiidka. Waxa kale oo ay ku xasiloon tahay xaaladaha caadiga ah, taas oo macnaheedu yahay in lagu kaydin karo muddo dheer iyada oo aan hoos loo dhigin.
2,4,5-Trifluorophenylacetic Acid waa mid aad u kala duwan waxaana loo isticmaali karaa isku dhafka xeryahooda kale ee adag ee ka baxsan sitagliptin dhexdhexaadinta. Waxay leedahay codsiyo warshadeed oo kala duwan, oo ay ku jiraan soo saarista agrochemicals, resins, iyo dhexdhexaadiyeyaasha. Waxa kale oo loo isticmaali karaa sidii qalab bilow ah oo loogu talagalay isku-darka noocyo badan oo unugyo leh codsiyo kala duwan.
Shirkaddayada, waxaanu ku faanaynaa inaanu macaamiishayada siino 2,4,5-Trifluorophenylacetic acid oo tayo sare leh. Alaabtayadu waxay la kulmeysaa heerarka tayada ugu sarreeya waxaana la soo saaray iyadoo la raacayo tilmaamo adag si loo hubiyo joogtaynta iyo nadiifnimada.
Gebagebadii, 2,4,5-Trifluorophenylacetic Acid waa iskudhis aad u faa'iido badan oo noqday qayb qiimo leh oo soo saarista sitagliptin, oo ah dawada safka hore ee nooca II ee sonkorowga. Kala duwanaanshaheeda iyo waxtarkeeda ayaa ka dhigaya hanti qiimo leh oo ku jirta warshadaha dawooyinka iyo kiimikada, waxaanan ku faraxsanahay inaan siino macaamiisheena tayada sare leh ee 2,4,5-Trifluorophenylacetic acid.
