2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine(CAS#865363-93-5)
Soo bandhigida 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5), analooga nucleoside-ka ah oo gogol-xaaraya oo loo dejiyay inuu wax ka beddelo cilmiga bayoolajiga molecular iyo cilmi-baarista dawooyinka. Xaruntan hal-abuurka leh waxaa loogu talagalay in lagu wanaajiyo fahamka isdhexgalka aashitada nukliyeerka iyo hababka gacanta, taasoo ka dhigaysa qalab qiimo leh oo loogu talagalay cilmi-baarayaasha iyo saynisyahannada si isku mid ah.
2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine waxaa lagu gartaa wax ka beddelka qaabdhismeedka gaarka ah, oo ay ku jiraan beddelka ethynyl iyo fluorine ee boosaska 4′ iyo 2′, siday u kala horreeyaan. Wax ka beddelladani kaliya ma wanaajiyaan xasilloonida xarunta iyo helitaankooda bioavailability laakiin sidoo kale waxay kor u qaadaan awoodda ay u leeyihiin inay gudaha u galaan xuubabka gacanta, taasoo u oggolaanaysa dhalmo waxtar leh iyo qaadashada hababka noole ee kala duwan.
Analoogga nucleoside-ka ayaa muujiyay karti rajo leh codsiyo kala duwan, oo ay ku jiraan cilmi-baarista fayraska iyo ka hortagga kansarka. Awooddeeda in ay ku ekaato nucleosides dabiiciga ah iyada oo la soo bandhigayo sifooyin biochemical oo kala duwan ayaa ka dhigaysa musharax ku habboon horumarinta wakiilada daweynta cusub. Cilmi-baarayaashu waxay isticmaali karaan 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine si ay u daraaseeyaan RNA iyo DNA synthesis, baaraan isdhexgalka enzyme, iyo sahaminta hababka ficilka daawooyinka jira.
Marka lagu daro codsiyadeeda cilmi-baarista, xaruntani waxay sidoo kale diyaar u tahay inay door muhiim ah ka qaadato horumarinta daaweynta jiilka soo socda. Iyada oo la siinayo aragtiyo ku saabsan dabeecadda aashitada nucleic iyo isdhexgalka, 2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine waxay ka caawin kartaa qaabeynta daawaynta waxtarka leh iyo kuwa la beegsaday ee cudurro kala duwan.
Marka la soo koobo, 2′-Deoxy-4′-C-ethynyl-2-fluoroadenosine (CAS:865363-93-5) waa analog-gacan-goyn nucleoside ah oo bixisa fursado aan la soo koobi karin oo loogu talagalay cilmi-baarista iyo horumarinta bayoolaji molecular iyo farmashiyaha. Ku qaabiso mustaqbalka sahaminta sayniska ee xaruntan gaarka ah oo fur fursadaha cusub ee dadaalkaaga cilmi-baarista.
