2-Chloro-3-fluoro-6-picoline (CAS# 374633-32-6)
Hordhac
Muuqashada: Sida caadiga ah midab la'aan iyo dareeraha jaalaha ah ee khafiifka ah, muuqaalkani wuxuu muujinayaa in laga yaabo inuu u nugul yahay iftiinka iyo kulaylka, waxaana lagama maarmaan ah in la qaado tallaabooyin si looga fogaado iftiinka iyo heerkulka inta lagu jiro kaydinta iyo gaadiidka, sida isticmaalka dhalooyinka dhalada brown iyo kaydinta. oo ku jira bakhaar qabow si looga hortago midab kale oo qoto dheer iyo xumaan.
Solubility: xaruntu waxay leedahay milmayn wanaagsan oo ku jira dareerayaasha dabiiciga ah ee caadiga ah, sida toluene iyo dichloromethane, waxay raacdaa mabda'a milanka la midka ah, waxayna leedahay xiriir la leh dareerayaasha organic iyadoo loo eegayo qaybta hydrophobic ee molecule; Si kastaba ha ahaatee, milanka biyuhu aad buu u hooseeyaa, isku xidhka haydarojiin xooggan ee ka dhexeeya molecules-ka biyaha way adagtahay in uu si wax ku ool ah u jebiyo unugyadu, taas oo adkeynaysa in la kala firdhiyo.
Barta karkarinta iyo cufnaanta: Xogta barta karkarinta waxay si dhow ula xiriirtaa isbeddelkeeda waxayna bixin kartaa cabbirada muhiimka ah ee hawlgallada sida nadiifinta iyo nadiifinta, laakiin nasiib darro qiimaha barta karkarinta gaarka ah si weyn looma shaacin. Cufnaantiisu wax yar ayay ka sarraysaa kan biyaha, fahamka cufnaanta ayaa kaa caawin karta in si sax ah loo qiyaaso xidhiidhka beddelka mugga-balaadhan ee hawlgallada tijaabada ah ama hababka warshadaha sida wareejinta dareeraha iyo cabbirka saxda ah.
Waxyaabaha kiimikada
Falcelinta beddelka: Atamka koloriinta iyo atamka fluorine ee ku jira molecule waa goobaha falcelinta ee suurtogalka ah. Dareen-celinta beddelka nucleophilic, nucleophiles xooggan waxay weerari karaan goobaha ay ku yaalliin chlorine iyo atomyada fluorine, beddelaan atamka u dhigma, waxayna abuuraan derivatives pyridine cusub. Tusaale ahaan, waxaa lagu daray qaar ka mid ah nucleophiles-ka nitrogen-ku jira iyo baaruud-ka kooban si loo horumariyo xeryahooda heterocyclic taxane ah oo nitrogen ka kooban oo leh qaabab aad u adag oo loogu talagalay helitaanka daroogada ama isku-dhafka walxaha.
Dareen-celinta dib-u-celinta: giraanta pyridine lafteedu waa mid deggan, laakiin marka oksidants xooggan, sida potassium permanganate iyo hydrogen peroxide lagu daro xaaladaha acidic, oksaydhisku wuxuu dhici karaa, taasoo keentay burbur ama wax ka beddelka qaab dhismeedka giraanta pyridine; Taa beddelkeeda, oo leh wakiilka yaraynta ku habboon, sida hydrides birta, aragti ahaan waa suurtogal in hydrogenation of bonds intramolecular unsaturated.
Afar, habka isku-dhafka
Dariiqa isku dhafan ee caadiga ah waa in laga bilaabo soosaarayaasha pyridine ee fudud oo si tartiib tartiib ah loo dhiso qaab-dhismeedka bartilmaameedka iyada oo loo marayo falcelinta halogenation iyo fluorination. Maaddada bilawga ah ee pyridine-ka ayaa marka hore si la xushay methylated iyo kooxaha methyl isku mar ayaa la soo bandhigay; Ka dib isticmaal reagen-yaasha halogenation, sida koloriin iyo koloriin dareere ah, oo leh kiciyayaal ku habboon iyo xaaladaha falcelinta, si loo gaadho hordhaca atamka koloriinta; Ugu dambayntii, reagen-yaasha fluorine-ka ah, sida Selectfluor, ayaa loo isticmaalay in si sax ah loo fluoriyeeyo goobta la beegsanayo si loo helo 2-chloro-3-fluoro-6-methylpyridine.
Adeegsada
Isku-darka daroogada ayaa dhexdhexaad ah: qaab-dhismeedkeeda gaarka ah waxaa jecel farmashiyeyaasha daawada, waana dhexdhexaad tayo sare leh oo loogu talagalay horumarinta dawooyinka cusub ee bakteeriyada, fayraska, iyo antitumor. Qalabka elektaroonigga ah iyo qaab-dhismeedka boosaska ee giraangiraha pyridine iyo beddelaadkooda ayaa si gaar ah ugu xidhi kara bartilmaameedka borotiinka ee vivo, waxaana la filayaa in loo beddelo maaddooyin firfircoon oo leh waxtar aad u wanaagsan ka dib beddelka tallaabooyin badan oo xiga.
Sayniska walxaha: Marka la eego isku-dhafka walxaha organic, waxaa loo isticmaali karaa in lagu soo saaro qalabka polymer-ka shaqeeya, qalabka fluorescent, iwm. guryaha, iyo kor u qaadida horumarinta tignoolajiyada casriga ah sida qalabka casriga ah iyo alaabta bandhigga.
